Fluoride
Fluoride in Dentistry: Caries Prevention, Fluorosis Risk, and the Neurotoxicity Debate
Topical fluorides reduce caries by 24–43 percent. The neurotoxicity debate concerns systemic exposure above 1.5 mg/L in drinking water and is not transferable to topical application.
Evidence Summary Box
Evidence Level: high (A)
Strength of Conclusion: strong
Primary Direction: Benefit (topical caries prevention)
Assessment Status: fully assessed
Assessed Studies: 30
Quality Mix: 10 primary / 20 with reservations / 0 critical
High-Weight Studies: 14
Bias Risk: low to moderate
CoI Risk: low
Article Type: Exposure
Source Integrity: clean